Huge disadvantages exist nevertheless. Most if not all scanners do work solely in the Internet Explorer and require Active X controls to be active. This could pose a security risk by itself and it is therefor advised to use those scanners as a last resort. Only a few scanners work with Firefox and none seem to work with Opera. On to the list:
Bitdefender (IE only)
Command on Demand (IE only)
eTrust (IE only)
F-Secure (IE only)
Kapersky (IE only)
McAfee (IE and Firefox)
Pandasoftware (IE only)
Symantec (IE only)
TrendMicro (IE, Firefox and Mozilla)